The worldwide swine industry is heavily affected by Mycoplasma, a disease that reduces growth rates, increases medication costs, and decreases productivity. Therefore, various programs have been developed to combat its adverse effects, including better management practices, strict biosecurity measures, and vaccination programs, thus improving the welfare of pigs and increasing the profitability of the swine industry by reducing the prevalence of bacteria in swine populations. In this episode, Dr. Paul Yeske discusses different approaches to the elimination of Mycoplasma and presents a new twist on the process.